Ganglia should work out of the box but will be using the default settings. Here you can configure a few settings (mostly names) for your ganglia setup so that it will display the correct information about your nodes and/or cluster grid upon startup.
Client nodes can have multiple network interfaces. Specify which interface should be used for sending/receiving ganglia monitoring information:
When multiple clusters are in use it might make sense to use different multicast ports for the client nodes such that the data from different clusters doesn't interfere. Specify which multicast port should be used for sending ganglia monitoring information: